CARDIOMYOCYTE OGA HAPLOINSUFFICIENCY INCREASES O-GLCNACYLATION BUT HASTENS VENTRICULAR DYSFUNCTION FOLLOWING MYOCARDIAL INFARCTION.

Cardiomyocyte Oga haploinsufficiency increases O-GlcNAcylation but hastens ventricular dysfunction following myocardial infarction.

RationaleThe beta-O-linkage of N-acetylglucosamine (i.e., O-GlcNAc) to proteins is a pro-adaptive response to cellular insults.To this end, increased protein O-GlcNAcylation improves short-term survival of cardiomyocytes subjected to acute injury.This observation has been repeated by multiple groups and in multiple models; however, whether increase

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A study protocol of a randomised controlled trial to investigate if a community based strength training programme improves work task performance in young adults with Down syndrome

Abstract Background Muscle strength is important for young people with Down syndrome as they make the transition to adulthood, seattle seahawks socks because their workplace activities typically emphasise physical rather than cognitive skills.Muscle strength is reduced up to 50% in people with Down syndrome compared to their peers without disabilit

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A Rare Cause of Hand Infection: Streptococcus Constellatus

viqua-f4 Hand infections represent common medical and surgical challenges that endanger delicate structures with severe consequences if not promptly addressed.Early identification and management are essential to achieve optimal outcomes.To the best of our knowledge this is the first reported case caused by Streptococcus constellatus, in which a sev

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